Johns Hopkins Hospital
Transplant Surgery
Harvey 611
600 North Wolfe Street
Baltimore, MD 21287
(410) 502-6590
Education:
Rice University.
B.S. Electrical Engineering,
1992.
B.A. Computer Science, 1992.
Johns Hopkins University.
M.D. School of Medicine, 1996.
Mentor: Martha Zeiger, M.D.
Postgraduate:
Johns Hopkins Hospital, Johns
Hopkins University School of Medicine.
Junior Resident, Department of
Surgery, 7/96-6/98.
Chair: John L. Cameron, M.D.
Massachusetts General Hospital, Harvard
University.
Research Fellow, Pediatric
Surgery, 7/98-6/01.
Mentor: Patricia K. Donahoe,
M.D.
Johns Hopkins Hospital, Johns
Hopkins University School of Medicine.
Senior/Chief Resident,
Department of Surgery, 7/01-6/04.
Chair: John L. Cameron, M.D.
Johns Hopkins Hospital, Johns
Hopkins University School of Medicine.
Instructor, Division of
Transplantation, Department of Surgery, 7/04-Present.
Academic Honors and Awards:
Sallyport
Community Service Award, Rice University, 1992
Executive
Cabinet Award for Outstanding Service, Rice University, 1992
Rice
University Most Outstanding Engineering Graduate, 1992
George
D. Zuidema Award for Laboratory Research, 1999
Presley-Carl
Zeiss Young Investigator Award, 2001
Genentech
Endocrinology and Metabolism Award, 2001
Upjohn
Award for Outstanding Clinical Research, 2002
Research Support, Past and
Present:
American
College of Surgeons Resident Research Award, 1998-2000
National
Research Scientist Award, 1999-2001
American
Society for Transplant Surgeons Award, 2004-2006
National
Center for Supercomputing Applications Grant, 2005-2006
Peer Reviewed Publications:
(*
indicates equal contributions of two authors for the purposes of first
authorship)
1.
McKee M, Segev D, Wise B, Case B, Neu A, Fivush B,
Colombani P. Initial experience with FK506 in pediatric renal transplant
patients. J Pediatr Surg. 1997
May;32(5):688.
2.
Takiyama Y, Saji M, Clark DP, Phillips GS, Segev DL,
Smallridge RC, Westra WH, Udelsman R, Zeiger MA. PCR-based microsatellite
analysis of fine needle aspirations (FNA) from Hurthle cell neoplasms. Thyroid. 1997 Dec;7(6):853.
3.
Ringel MD, Saji M,
Schwindinger WF, Segev D, Zeiger MA, Levine MA. Absence
of activating mutations of the genes enconding the alpha-subunits of G11 and Gq
in thyroid neoplasia. J Clin Endocrinol
Metab. 1998 Feb;83(2):554.
4.
Segev DL, Saji M, Phillips GS, Westra
WH, Takiyama Y, Piantadosi S, Smallridge RC, Nishiyama RH, Udelsman R, Zeiger
MA. PCR-based microsatellite polymorphism analysis of follicular and Hurthle
cell neoplasms of the thyroid. J Clin
Endocrinol Metab. 1998 Jun;83(6):2036.
5.
Segev DL, Ha TU, Tran TT, Kenneally M,
Harkin P, Jung M, MacLaughlin DT, Donahoe PK, Maheswaran S. Mullerian
inhibiting substance inhibits breast cancer cell growth through an NFkappa
B-mediated pathway. J Biol Chem. 2000
Sep 15;275(37):28371.
6.
Ha TU, Segev DL, Barbie D, Masiakos PT, Tran TT,
Dombkowski D, Glander M, Clarke TR, Lorenzo HK, Donahoe PK, Maheswaran S.
Mullerian Inhibiting Substance inhibits ovarian epithelial cell growth through
an Rb independent mechanism. J Biol Chem.
2000 Nov 24;275(47):37101.
7.
Stephen AE, Masiakos PT, Segev DL, Vacanti JP,
Donahoe PK, MacLaughlin DT. Tissue Engineered Cells Producing Complex
Recombinant Proteins Inhibit Ovarian Cancer In Vivo. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3214.
8.
Segev DL, Hoshiya Y, Stephen AE, Hoshiya
M, Tran TT, MacLaughlin DT, Donahoe PK, Maheswaran S. Mullerian Inhibiting
Substance Regulates NFkB Signaling and Growth of Mammary Epithelial Cells in
vivo. J Biol Chem 2001 Jul
20;276(29):26799.
9.
Segev DL*/Hoshiya Y*, Hoshiya M, Tran
TT, Carey J, Stephen AE, MacLaughlin DT, Donahoe PK, Maheswaran S. Mullerian
Inhibiting Substance Regulates NFkB Signaling in the Prostate in vitro and in
vivo. Proc Natl Acad Sci U S A. 2002
Jan 8;99(1):239.
10. Stephen
AE, Segev DL, Ryan DP, Mullins ME, Kim SH, Schnitzer JJ, Doody DP. The
Diagnosis of Acute Appendicitis in a Pediatric Population: To CT or not to CT. J Pediatr Surg. 2003 Mar;38(3):367.
11. Hoshiya
Y, Gupta V, Segev DL, Hoshiya M, Carey JL, Sasur LM, Tran TT, Ha TU,
Maheswaran S. Mullerian Inhibiting Substance induces NFkB signaling in breast
and prostate cancer cells. Mol Cell Endocrinol 2003 Dec;211(1):43.
12. Segev DL, Gentry
SE, Warren DS, Reeb B, Montgomery RA. Kidney Paired Donation and optimizing the
use of live donor organs. JAMA. 2005 Apr 20;293(15):1883-90.
13. Segev DL*/Molmenti
EP*, Arepally A, Hong J, Rai R, Thuluvath PJ, Klein AS. The Utility of TIPS in
the management of Budd-Chiari Syndrome. Ann Surg. 2005 Jun;241(6):978-983.
14. Gentry
SE, Segev DL, Montgomery RA. A comparison of populations served by
Kidney Paired Donation and List Paired Donation. Am J Transplant. 2005
Aug;5(8):1914-21.
15. Segev DL,
Simpkins CE, Warren DS, King KE, Maley WR, Melancon JK, Cooper M, Kozlowski T,
Montgomery RA. ABO incompatible high-titer renal transplantation without
splenectomy or anti-CD20 treatment. Am J Transplant. 2005. In press.
16. Segev DL, Gentry
SE, Melancon JK, Montgomery RA. Characterization of waiting times in a
simulation of kidney paired donation. Am J Transplant. 2005. In press.
17. Montgomery
RA, Zachary AA, Ratner LE, Segev DL, Hiller JM, Houp J, Cooper M,
Kavoussi L, Jarrett T, Burdick J, Maley WR, Melancon JK, Kozlowski T, Simpkins
CE, Phillips M, Desai A, Collins V, Reeb B, Kraus E, Rabb H, Leffell MS, Warren
DS. Kidney Paired Donation permits successful transplantation with incompatible
live kidney donors. JAMA. 2005. In
press.
Invited Reviews:
1. Lipsett P, Segev DL, Colombani P.
Biliary atresia and biliary cysts. Baillieres
Clin Gastroenterol. 1997 Dec;11(4):619.
2. Segev DL, Umbricht C, Zeiger MA.
Molecular pathogenesis of thyroid cancer. Surg Oncol 2003 Aug;12(2):69.
3. Segev DL, Clark DP, Zeiger MA,
Umbricht C. Beyond the suspicious thyroid fine needle aspirate. Acta Cytol
2003 Sep-Oct;47(5):709.
4. Segev DL, Gentry SE, Melancon JK,
Montgomery RA. Kidney Paired Donation: transplanting the incompatible. Surgery.
In press.
Book Chapters:
1.
Segev D, Chen H. Vascular Access, in Principles
and Practice of Paediatric Anaesthesia (Bissonnette, Dalens, eds)
Mc-Graw-Hill. 2002.
2.
Segev DL, Donahoe PK, Doody DP.
Congenital Anomalies, in Esophageal Surgery, 2nd Edition (Pearson,
Cooper, et al., eds) Harcourt. 2002.
3.
Segev DL, Doody DP. Peritonitis, in Current
Pediatric Therapy, 17th Edition (Burg, Ingelfinger, Polin, and Gershon,
eds) W.B. Saunders. 2002.
4.
Segev DL, Doody DP. Esophageal Foreign
Bodies in Children, in Surgery of the Trachea and Bronchi (Grillo, ed)
B.C. Decker. 2003.
5.
Segev DL, Paidas CN. Esophageal Atresia
and Tracheoesophageal Fistula, in Current Surgical Therapy, 7th Edition
(Cameron, ed) Mosby. 2004.
6.
Segev DL, Colombani P. Acute
Appendicitis, in Advanced Therapy for Gastroenterology and Liver Disease,
5th Edition (Bayless and Diehl, eds) B.C. Decker. 2005.
7.
Camp MS, Segev DL. Peritonitis, in Current
Pediatric Therapy, 18th Edition (Burg, Ingelfinger, Polin, and Gershon,
eds) W.B. Saunders. 2005.
Books:
1. Surgical Dictation Pocket Survival Guide
(Segev, ed) International Medical Publishing. 2004.
2. Incompatible Solid Organ Transplantation
(Segev and Montgomery, eds) In preparation.
Selected Presentations at National Meetings:
1.
Segev DL, Saji M, Westra WH,
Takiyama Y, Udelsman R, Zeiger MA. Differentiating Hurthle cell
adenomas from carcinomas of the thyroid by PCR-based microsatellite
polymorphism analysis. Surgical Forum,
82nd Annual Clinical Congress, American College of Surgeons. 1996; 47:501.
2.
Segev DL, Saji M, Westra WH,
Udelsman R, Zeiger MA. PCR-based microsatellite polymorphism analysis of
thyroid follicular neoplasms. 49th Annual Cancer Symposium, Society of
Surgical Oncology. 1996.
3.
Segev DL, Ha T, Donahoe PK, Maheswaran S. Mullerian
Inhibiting Substance inhibits growth of breast cancer cells through an NFkB
dependent pathway. Surgical Forum, 85th Annual Clinical Congress, American
College of Surgeons. 1999.
4.
Lillemoe KD, Segev D,
Petrofski JA, Talamini MA, Bell WR, Cameron JL. Splenectomy for massive
splenomegaly: Indications and outcome. Gastroenterology
1999 Apr;116(4):S0151.
5.
Segev DL, Donahoe PK, Maheswaran S. MIS selectively
induces IEX-1S in breast cancer cells. Gordon Conference on Cancer Research.
2000.
6.
Stephen AE, Masiakos PT, Segev DL, Vacanti JP, Donahoe PK,
MacLaughlin DT. Tissue Engineered Organs Designed to Regress Abnormal Tissue. Surgical Forum, 86th Annual Clinical
Congress, American College of Surgeons. 2000; 50:309.
7.
Segev DL, Donahoe PK, Maheswaran S. MIS induces the cell
cycle inhibitor p27, alters Rb/E2F family proteins, and causes apoptosis and
growth arrest of breast cancer cells. Surgical
Forum, 86th Annual Clinical Congress, American College of Surgeons. 2000;
50:535.
8.
Segev DL, Hoshiya Y, Stephen AE, Hoshiya M, Tran TT,
Donahoe PK, Maheswaran S. Mullerian inhibiting substance inhibits normal breast
proliferation. FASEB J. 2001 Mar
7;15(4):A69.
9.
Segev DL, Hoshiya Y, Stephen AE, Hoshiya M, Tran TT,
Donahoe PK, Maheswaran S. Mullerian Inhibiting Substance Inhibits Breast
Proliferation. Federation for American Societies for Experimental Biology.
2001.
10.
Segev DL, Donahoe PK, Maheswaran S. Mullerian Inhibiting
Substance induces MYC and a cell cycle regulatory pathway in breast cancer
cells. 32nd Annual Meeting, American Pediatric Surgical Association.
2001.
11.
Segev DL, Stephen AE, Higgins C, Ryan DP, Doody DP.
Preoperative radiography in the management of constipation in children. 35th
Annual Meeting, Association of Academic Surgeons. 2001.
12.
Segev DL, Warren DS, Simpkins CE, Hiller J, Zachary AA,
Graziani J, Montgomery RA. Results of conventional and unconventional paired
kidney exchanges. 3rd International Congress on Immunosuppression. 2004.
13.
Segev DL, Warren DS, Simpkins CE, Zachary AA, Cooper M,
Kozlowski T, Montgomery RA. Controlled hyperacute rejection. 3rd
International Congress on Immunosuppression. 2004.
14.
Gentry SE, Segev DL, Warren DS, Montgomery RA. Paired
Kidney Optimal eXchange (PKOX), a mathematically verifiable algorithm for
paired kidney exchange. 3rd International Congress on Immunosuppression.
2004.
15.
Weiss M, Segev DL, Hawxby A, Montgomery RA, Kraus E,
Cooper M, Molmenti E. Efficacy of basiliximab-based regimens for pancreatic
transplantation. ASTS 5th Annual State of the Art Symposium. 2004.
16.
Gentry SE, Segev DL, Montgomery RA. The Role for
Optimization in Paired Kidney Exchange: Advantages and Flexibility. Live
Donor Paired Kidney Exchange Consensus Meeting. 2005. Invited plenary
lecture.
17.
Segev DL. Future Horizons: Kidney Paired Donation. 13th
Annual UNOS Transplant Management Forum. 2005. Invited plenary lecture.
18.
Segev DL. Paired Kidney Exchange: Local Experience and
National Implications. UNOS Region 2 Transplant Forum. 2005. Invited
plenary lecture.
19.
Segev DL, Gentry SE, Warren DS, Reeb B, Montgomery RA.
Paired kidney exchange: the need for mathematically verifiable optimization. American
Transplant Congress. 2005.
20.
Segev DL. Living Donation – Paired Exchanges. 22nd
Annual Meeting of the Association for Organ Procurement Organizations.
2005. Invited plenary lecture.
21.
Segev DL. Matching algorithms for Kidney Paired Donation. California
Pacific Medical Center. 2005. Guest lecture.